In spasms. Myofascial pelvic pain has been known to

 

In
conclusion, botulism is a very dangerous toxin. If not treated could kill you
or cause you to be on a ventilator for many years. It can also be used in
chemical warfare and could kill millions of people in just a few short hours if
the full dose was administered. Watch out for double vision and slurred speech,
since those along with muscle weakness, tend to be the most common side
effects. Botulism can also be used to help with those pesky wrinkles or frown
lines as well as helping with some chronic pain in some cases.

Clostridium
botulinum toxin also has many other uses, for example it is the main ingredient
in Botox. Botox helps you to slow down the process of frown lines and wrinkles
by blocking signals from the nerves to the muscles (Resource 8). Other uses for the toxins include stopping of migraines, over
active bladder, and muscle spasms. Myofascial pelvic pain has been known to be
helped with Botox along with physical therapy in 58% of women (resource 9).

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To
treat any of the above botulisms the staff must identify what happened before
you came in. For example, if you ate some canned meat or honey or where you
traveled in the last 24 hours. Then usually they try to take blood work and a
stool sample. Problem with stool samples is it takes a few days to get the
results back, so it could be anywhere from 4-8 days before the staff realizes
that you have botulism. Good thing about the toxin, although it is best to get
it within you by 72 hours, it can still be administered up to 8 days after encountering
the toxin. The earlier it is treated the better, if it goes untreated there is
a 50 percent death rate that could occur (Resource 7). Also, if it goes
untreated and you don’t die, then the lasting effects could be upper respiratory
problems that could cause you to have to be on a ventilator or have physical
therapy. It can take several weeks or months for your muscle movement to return
due to the axons having to rebuild over time.

The neuromuscular junction, autonomic ganglia, postganglionic
parasympathetic nerve endings and postganglionic sympathetic nerve endings that
release acetylcholine. The heavy chain of the toxin binds selectively and
irreversibly to high affinity receptors at the presynaptic surface of
cholinergic neurons, and the toxin-receptor complex is taken up into the cell
by endocytosis. The disulphide bond between the two chains is cleaved and the
toxin escapes into the cytoplasm. The light (L) chain interact with different
proteins in the nerve terminals to prevent fusion of acetylcholine vesicles
with the cell membrane (Resource 6)

Food-borne
botulism among humans is a neuroparalytic disease resulting in respiratory and
muscular paralysis, occurring due to the ingestion of food contaminated with
botulinum toxins. (R4) It is hard to prove when you have food-borne botulism
since most people throw away their food when they are done, the test can only
happen on the specified food to determine you have it. Otherwise certain clinical
signs such as vomiting, constipation, and muscle loss are some of the symptoms
to help them determine food-borne toxin.

Infant
botulism is a neuroparalytic illness caused by the botulinum toxin of
Clostridium botulinum (resource 2). Most infants contract it under six months
due to not having a strong enough immune system, it is also the reason parents
aren’t supposed to give children honey under 1 year. Some symptoms include
being unable to swallow, upper respiratory problems, and muscle weakness.

             Wound botulism is
a rare infectious disease that is becoming a frequent complication of parental
drug use. (Resource 3). This can also happen with a sports or construction
injury. Some symptoms include muscle weakness, double vision, and slurred
speech.

Botulism comes in many
forms, there is wound, infant and food-borne botulism. Botulism is a neuro
-intoxication which is characterized by gastrointestinal, nervous and secretory
disorders induced by a toxin secreted by Clostridium botulinum (R5). Between
2004-2008 there were only 713 cases reported total across the United States (Resource
1). Botulism can be affected by anyone, it doesn’t happen in more races than
others.