The determine Young’s modulus that required producing experimentally determined

The study aimed was to create and confirm a computational
model that describes the deformation characteristics of the corneas mounted in
an artificial anterior chamber in response to an air puff.

A 2-D (COMSOL Multiphysics model) of an air jet impinging on
cornea mounted in an artificial anterior chamber was created. The CorVis ST, a
device that used to evaluate deformation response in the corneas, was generated
the physical air jet. This air jet was characterized by hot-wire anemometry to
obtain spatial flow velocity data. This hot wire was placed at the jet exit on
the CorVis and then moved outward with the control to distances of 3, 6, 9, 12,
15, 20, and 25 mm along the centerline. The duration of the hot wire anemometry
recordings continued 40 ms. Initial data of the temporal profile shows that the
peak velocity along the centerline during the air puff at distance 0 is over
100 m/s. On the other hand, the peak velocity reaches above 90 m/s at distances
between 9 and 12 mm from a nozzle of the CorVis ST. Accordingly, the model was
set at 100 m/s. The corneal dimensions were modeled by erecting an ellipse
inside an 8mm sphere that was sectioned to have a width of 12 mm. The cornea
section was mounted onto a rigid body into the model, representing the Barron’s
Artificial Anterior Chamber. Intraocular pressure (IOP) was manipulated to be
10, 20, 30, 40, and 50 mmHg. Deformation data from a corneal-scleral rim
mounted on an artificial anterior chamber at these pressures was used to
validate the model. At each pressure, the model was run iteratively to
determine Young’s modulus that required producing experimentally determined
deformations.

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 The result shows that
the maximum deformation of the model was matched to experimental deformation
data within 0.01% error. The Young’s moduli were 1.569, 1.740, 1.899, 2.099,
and 2.250 MPa for pressures at 10, 20, 30, 40, and 50 mmHg, respectively.

The model supports the relationship between the IOP and the
cornea that as IOP increases, the cornea will become stiffer. Future studies
will develop a 3D model as well as model the whole globe.